- Cell differentiation
- Cancer & Aging
- Neurological disorders
- Metabolic disorders
- Immune cell activation
- Bacterial/viral infection
- Inborn genetic defects
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Analysing Mitochondria at Higher Resolution with MitoPlate™ Technology Analysing Mitochondria at higher resolution with Biolog Technology MitoPlates™ provide a powerful new research tool by allowing scientists to run preconfigured sets of 96 mitochondrial function assays in one experiment. Mitochondria can be interrogated and characterised in novel ways, looking at rates of substrate metabolism, sensitivity to drugs and other chemicals, and effects of mutations in mitochondria-related genes. Assay Principle Mitochondrial function is assayed by measuring the rates of electron flow into and through the electron transport chain from metabolic substrates that produce NAD(P)H or FADH2 such as L-malate, succinate, pyruvate, etc. Each substrate follows a different route, using different transporters to enter the mitochondria and different dehydrogenases to produce NAD(P)H or FADH2, The electrons travel from the beginning (complex 1 or 2) to the distal portion of the electron transport chain where a tetrazolium redox dye (MC) acts as a terminal electron acceptor that turns purple upon reduction. Additional MitoPlate assays probe the sensitivity of the mitochondria to a set of 22 diverse inhibitors. Investigate how mitochondria change with: -
EcoPlates™ Examine environmental community diversity with Biolog EcoPlates™. Biolog EcoPlates provide a sensitive and reliable index of environmental change. This approach, called community-level physiological profiling (CLPP), is effective at distinguishing spatial and temporal changes in the metabolism of microbial communities. Microbial communities provide useful information about environmental change. Microorganisms are present in virtually all environments and are typically the first organisms to react to chemical and physical changes in the environment. Changes in microbial communities are often a precursor to changes in the health and viability of the environment as a whole. -
PreBioM™ Microplates Introducing The PreBioM™ line of microplates from Biolog. The microplates allow researchers studying human or animal gut microbiome communities to better understand metabolism of prebiotics. PreBioM plates offer a multidimensional phenotype profiling solution based on the impact of prebiotics on microbial function. The three-plate system contains 90 unique prebiotic substrates tailored to investigate the intricate interplay between prebiotics and the microbiome. These plates consist of a curated selection of prebiotic substrates of various molecular weights designed to characterise bacterial species and their metabolic pathways. The PreBioM plates, combined with the Biolog Odin family of instruments and software, provide a high throughput phenotypic solution compatible with a wide range of species, including the obligate anaerobes inhabiting the gut microbiome as well as microbial communities. -
Drug Discovery with Biolog Technologies BiOLOG’s Phenotype MicroArray™ Technology for Microbial and Mammalian Cells, and new MitoPlate™ assays are used by pharmaceutical companies, biotech’s and academic institutions to assist with new drug target identification and drug re-purposing, and any applications in the process of developing solutions for the treatment and curing of disease. Benefits of Phenotype MicroArrays in Drug Discovery:- Complement DNA microarrays. DNA microarrays allow scientists to measure the expression of thousands of genes of a cell under one growth condition, whereas Phenotype MicroArrays allow scientists to measure the effect of one gene in the cell under thousands of growth conditions.
- Provide rapid answers to critical questions about cellular properties in a simple, rapid, efficient, and cost- effective process.
- Provide rapid answers to how a gene of unknown function affects a cell at a physiological level.
- Provide cell-to-cell comparisons to find novel drug targets based on in vivo physiological differences.
- Provide a means to assay the effect of a drug on thousands of cellular targets under thousands of physiological states of the cell.
- Provide rapid answers to questions about how a new lead affects a cell at a biochemical level.
- Provide information on how new drug leads compare to and interact with existing drugs.
- Reduce the time and cost of slow and cumbersome animal, plant, or human studies in late development.
- Eliminate unproductive leads and projects, saving substantial R&D budget dollars that would be wasted in later development.
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Rapid and accurate determination of milk products chemical composition Semi-automatic and automatic versions from 100 up to 300 samples/hour The DairySpec FT uses FTIR spectroscopy for extremely accurate and reliable milk and dairy products chemical composition determination. Analysing up to 64 parameters simultaneously, the DairySpec FT is the optimal solution for the quality control of raw and processed materials. It gives access to the very fine analysis of milk and dairy products chemical composition (fat, proteins, casein, lactose, solids, urea, citric acid, fatty acids profil, FPD). Highly reliable and accurate for milk (raw, UHT, ...) and dairy products (cream, whey, permeate, retentate, ...) analysis. Adaptable to measure other products and parameters upon request. The spectra are standardised in real time to optimise calibrations transferability, stability and qualitative analysis (adulteration). Direct access to spectra for the development of new calibrations. 3M™ Clean-Trace™ Surface ATP UXL100 3M™ Clean-Trace™ Water Plus - Total ATP AQT200 3M™ Clean-Trace™ Water - Free ATP AQF100 -
Precise determination of somatic cell counts in all types of raw milk Semi-automatic and automatic versions from 100 up to 300 samples/hour The SomaCount FC delivers a rapid and accurate measurement somatic cell counts (SCC) for early mastitis detection in dairy milk. The smallest and most accurate instrument available for the counting of somatic cells in raw milk. Robust and reliable, it is used in both regulatory and high performing dairy laboratories around the globe. Flow cytometry at its best. For any laboratory where precision and performance is essential. It guarantees the accurate counting of somatic cells in milk at a maximum speed of 300 samples/hour (6 versions available: manual, 100, 150, 200, 250 and 300). The automatic SomaCount FC version is coupled to a conveyor system. -
Simultaneous Somatic Cell and Component Analysis Automatic versions from 100 up to 300 samples/hour System that combines the DairySpec FT for component analysis and the SomaCount FC for Somatic Cell Counting. The combination of these two flagship methods provides a complete overview of milk chemical and hygienic composition by analysing up to 64 parameters simultaneously. Different versions of DairySpec Combi are available (100, 150, 200, 250, 300) up to a maximum speed of 300 samples/hour. The sampling, sequencing and identification of the sample vials are functions performed by the Autosampler. Compatible with the ILAS 3000 ROBOT: Automation System for Milk Analysers -
Rapid & accurate determination of Somatic Cells and Chemical Composition in raw milk Automatic milk analysis at 600 samples/hour Engineered in accordance with Bentley Instruments’ rigorous design principles, the FTS combi provides precise and accurate measurements. The FTS combi comprises two separate modules — the Bentley Flow Cytometer (FCM), and the Bentley Fourier Transform Spectrometer (FTS). The FCM measures the somatic cell count of the milk samples while the FTS simultaneously measures the milk composition up to 64 parameters (fat, protein, lactose, casein, fatty acids profil, minerals, blood BHB,...). After first being stirred, the milk is drawn from a sample vial and delivered to both measurement modules. The sampling, sequencing and identification of the sample vials are functions performed by the Autosampler. 3M™ Clean-Trace™ Surface ATP UXL100 3M™ Clean-Trace™ Water Plus - Total ATP AQT200 3M™ Clean-Trace™ Water - Free ATP AQF100 -
Real-Time enumeration of individual Bacteria & Somatic Cells in raw milk Automatic milk analysis at 200 samples/hour The BactoCount series (50, 100, 150, 200) uses flow cytometry for the real-time determination of total flora and somatic cells in raw milk up to a maximum speed of 200 analysis/hour. The high speed of this model makes it the ideal solution for mid to large size laboratories that need an easy to maintain, exceptionally fast bacteria counting system. The BactoCount IBC Series uses a proprietary process based on flow cytometry for the rapid, highly accurate, reliable and multiplex enumeration of individual bacteria and somatic cells in raw milk. The sampling, sequencing and identification of the sample vials are functions performed by the Autosampler.Compatible with the ILAS 4000 ROBOT: Automation System for Bacteria Counter
Validated to be at least equivalent to the EN-ISO 4833-1:2013 and 4833-2:2013 reference methods for the enumeration of microorganisms in raw cow milk (Certificate n° 2013LR44)
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Real-Time enumeration of individual Bacteria & Somatic Cells in raw milk Semi-Automatic version up to 50 analysis/hour The new BactoCount IBCm 3.0 is a semi-automated instrument that uses a proprietary process based on next-generation flow cytometry for the rapid, highly accurate, reliable and multiplex enumeration of individual bacteria and somatic cells in raw milk. The rapid test for bacteria and somatic cells makes it the ideal solution for any processing plant or laboratory involved in the quality assessment of milk. The instrument offers multiplex applications thanks to its unique dedicated platform. Up to two applications can be run simultaneously on a given sample. The overall design of the instrument has also been designed to allow ease of access and maintenance. With this in mind, IBCm 3.0 embeds a new kinetic, self aligned flow cell mounting system. The BactoCount IBCm 3.0 can be equipped with a conveyor, automating the sampling at a maximum rate of 50 analysis/hour. The sampling, sequencing and identification of the sample vials are functions performed by the Autosampler.Compatible with the ILAS 4000 ROBOT: Automation System for Bacteria CounterValidated to be at least equivalent to the EN-ISO 4833-1:2013 and 4833-2:2013 reference methods for the enumeration of microorganisms in raw cow milk (Certificate n° 2013LR44)
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Introducing the ILAS 3000 Robot The combination of the Bentley Instruments and high-tech robotics allows the complete automation and standardisation of the analytical chain and MSDs reduction. With the ILAS 3000 Robot, an operator can manage up to 3 lines simultaneously. Always with a goal of enhanced productivity and standardisation, this system analyses up to 600 samples/hour. Compatible with the Combi FTS Series: Infrared Analyser & Somatic Cells Counter and alternative methods. The Standardisation Tray used for Laboratory Automation is compatible with the ILAS Robot. -
Introducing the ILAS 4000 Robot The new ILAS 4000 robot is a unique solution to automate and standardise sample preparation for bacteria counters up to a maximum speed of 200 samples/hour. Fully refrigerated, samples are identified (RFID chips or barcode), homogenised, uncapped and analysed. The vials are automatically recapped after analysis and place back in their original tray position. Compatible with the BactoCount IBC Series: Bacteria & Somatic Cells Counter and alternative methods. The Standardisation Tray used for Laboratory Automation is compatible with the ILAS Robot.